منابع مشابه
Defensins and Innate Immunity of the Mammalian Small Intestine
The release of gene-encoded antimicrobial peptides by epithelial cells is thought to contribute to innate mucosal immunity. Defensins are a predominant class of such antimicrobial peptides in mammals. These cysteine-rich cationic peptides have antibiotic activity against a wide range of bacteria and other microbes. In the mammalian small intestine, Paneth cells at the base of the crypts of Lieb...
متن کاملPaneth cells: leukocyte-like mediators of innate immunity in the intestine.
Paneth cells are secretory intestinal epithelial cells located at the base of the crypts of Lieberkühn in the small intestine. They display prominent cytoplasmic granules, containing antibacterial proteins such as lysozyme, secretory phospholipase A2 type IIA, and alpha-defensins, which are released into the intestinal lumen in response to a range of stimuli. In this, they resemble circulating ...
متن کاملInnate immunity in the lungs.
Innate immunity is a primordial system that has a primary role in lung antimicrobial defenses. Recent advances in understanding the recognition systems by which cells of the innate immune system recognize and respond to microbial products have revolutionized the understanding of host defenses in the lungs and other tissues. The innate immune system includes lung leukocytes and also epithelial c...
متن کاملInnate immunity
From the discovery of antibodies in the late nineteenth century until very recently, the focus of most research in immunology has been the so-called adaptive immune response. Adaptive immune responses are highly specific for a given microorganism and it is the T and B lymphocytes of the adaptive immune response, and the antibodies produced by the B lymphocytes, that are responsible for lasting ...
متن کاملMitochondria in innate immunity.
Mitochondria are cellular organelles involved in host-cell metabolic processes and the control of programmed cell death. A direct link between mitochondria and innate immune signalling was first highlighted with the identification of MAVS-a crucial adaptor for RIGI-like receptor signalling-as a mitochondria-anchored protein. Recently, other innate immune molecules, such as NLRX1, TRAF6, NLRP3 a...
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ژورنال
عنوان ژورنال: Journal of Innate Immunity
سال: 2011
ISSN: 1662-8128,1662-811X
DOI: 10.1159/000333043